Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2072726..2073228 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag LQ127_RS09975 Protein ID WP_000767831.1
Coordinates 2072974..2073228 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LQ127_RS09970 Protein ID WP_001259255.1
Coordinates 2072726..2072977 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS09945 (2067903) 2067903..2068970 - 1068 WP_042046651.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LQ127_RS09950 (2068970) 2068970..2070040 - 1071 WP_053290108.1 histidinol-phosphate transaminase -
LQ127_RS09955 (2070037) 2070037..2071341 - 1305 WP_001446927.1 histidinol dehydrogenase -
LQ127_RS09960 (2071347) 2071347..2072246 - 900 WP_053290109.1 ATP phosphoribosyltransferase -
LQ127_RS09965 (2072392) 2072392..2072442 - 51 WP_001364200.1 his operon leader peptide -
LQ127_RS09970 (2072726) 2072726..2072977 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LQ127_RS09975 (2072974) 2072974..2073228 + 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LQ127_RS09980 (2073311) 2073311..2074135 + 825 WP_000754737.1 SDR family oxidoreductase -
LQ127_RS09985 (2074181) 2074181..2075110 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LQ127_RS09990 (2075325) 2075325..2075387 + 63 WP_010723108.1 membrane protein YoeI -
LQ127_RS09995 (2075377) 2075377..2076735 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
LQ127_RS10000 (2076914) 2076914..2077972 + 1059 WP_053290110.1 thiosulfate utilization transporter TsuA/YeeE -
LQ127_RS10005 (2077986) 2077986..2078213 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T295882 WP_000767831.1 NZ_OW967966:2072974-2073228 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT295882 WP_001259255.1 NZ_OW967966:2072726-2072977 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References