Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 833291..833984 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LQ127_RS03980 Protein ID WP_000415584.1
Coordinates 833291..833587 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LQ127_RS03985 Protein ID WP_000650107.1
Coordinates 833589..833984 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS03945 (828379) 828379..828693 - 315 WP_000958598.1 putative quinol monooxygenase -
LQ127_RS03950 (828724) 828724..829305 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LQ127_RS03955 (829624) 829624..829956 + 333 WP_023149630.1 DUF2645 family protein -
LQ127_RS03960 (830002) 830002..831351 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LQ127_RS03965 (831348) 831348..832007 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LQ127_RS03970 (832159) 832159..832551 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LQ127_RS03975 (832604) 832604..833086 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LQ127_RS03980 (833291) 833291..833587 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LQ127_RS03985 (833589) 833589..833984 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LQ127_RS03990 (834117) 834117..835724 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LQ127_RS03995 (835862) 835862..838120 + 2259 WP_025693397.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T295878 WP_000415584.1 NZ_OW967966:833291-833587 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT295878 WP_000650107.1 NZ_OW967966:833589-833984 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References