Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 708591..709390 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag LQ127_RS03355 Protein ID WP_000347273.1
Coordinates 708591..709055 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag LQ127_RS03360 Protein ID WP_001308975.1
Coordinates 709055..709390 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS03325 (703592) 703592..704026 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LQ127_RS03330 (704044) 704044..704922 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ127_RS03335 (704912) 704912..705691 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ127_RS03340 (705702) 705702..706175 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ127_RS03345 (706198) 706198..707478 - 1281 WP_023908831.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ127_RS03350 (707727) 707727..708536 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ127_RS03355 (708591) 708591..709055 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ127_RS03360 (709055) 709055..709390 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ127_RS03365 (709539) 709539..711110 - 1572 WP_023908830.1 galactarate dehydratase -
LQ127_RS03370 (711485) 711485..712819 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
LQ127_RS03375 (712835) 712835..713605 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T295877 WP_000347273.1 NZ_OW967966:c709055-708591 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT295877 WP_001308975.1 NZ_OW967966:c709390-709055 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References