Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4526897..4527499 Replicon chromosome
Accession NZ_OW967795
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name higB Uniprot ID A0A3L4YH82
Locus tag LQ148_RS21810 Protein ID WP_000897303.1
Coordinates 4527188..4527499 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ148_RS21805 Protein ID WP_000356397.1
Coordinates 4526897..4527187 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS21775 (4522202) 4522202..4523131 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
LQ148_RS21780 (4523313) 4523313..4523555 - 243 WP_001068514.1 CopG family transcriptional regulator -
LQ148_RS21785 (4523845) 4523845..4524693 + 849 WP_001038651.1 hypothetical protein -
LQ148_RS21790 (4524718) 4524718..4525458 + 741 WP_022296249.1 hypothetical protein -
LQ148_RS21795 (4525643) 4525643..4525861 - 219 WP_001251293.1 CopG family transcriptional regulator -
LQ148_RS21800 (4526260) 4526260..4526538 - 279 WP_001296612.1 hypothetical protein -
LQ148_RS21805 (4526897) 4526897..4527187 - 291 WP_000356397.1 NadS family protein Antitoxin
LQ148_RS21810 (4527188) 4527188..4527499 - 312 WP_000897303.1 hypothetical protein Toxin
LQ148_RS21815 (4527728) 4527728..4528636 + 909 WP_001385591.1 alpha/beta hydrolase -
LQ148_RS21820 (4528700) 4528700..4529641 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LQ148_RS21825 (4529686) 4529686..4530123 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
LQ148_RS21830 (4530120) 4530120..4530992 - 873 WP_000920763.1 virulence factor BrkB family protein -
LQ148_RS21835 (4530986) 4530986..4531585 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12302.33 Da        Isoelectric Point: 10.0233

>T295843 WP_000897303.1 NZ_OW967795:c4527499-4527188 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGRLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT295843 WP_000356397.1 NZ_OW967795:c4527187-4526897 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4YH82

Antitoxin

Source ID Structure

References