Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2357066..2357628 Replicon chromosome
Accession NZ_OW967795
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag LQ148_RS11285 Protein ID WP_000605675.1
Coordinates 2357066..2357344 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag LQ148_RS11290 Protein ID WP_000781370.1
Coordinates 2357344..2357628 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS11260 (2352654) 2352654..2353085 - 432 WP_000152305.1 peroxiredoxin OsmC -
LQ148_RS11265 (2353429) 2353429..2353644 + 216 WP_000495774.1 biofilm-dependent modulation protein -
LQ148_RS11270 (2353746) 2353746..2353883 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
LQ148_RS11275 (2354039) 2354039..2355736 + 1698 WP_001607334.1 malate dehydrogenase -
LQ148_RS11280 (2355870) 2355870..2356880 + 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
LQ148_RS11285 (2357066) 2357066..2357344 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ148_RS11290 (2357344) 2357344..2357628 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
LQ148_RS11295 (2357856) 2357856..2358509 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
LQ148_RS11300 (2358502) 2358502..2359386 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
LQ148_RS11305 (2359399) 2359399..2362446 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T295836 WP_000605675.1 NZ_OW967795:2357066-2357344 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT295836 WP_000781370.1 NZ_OW967795:2357344-2357628 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References