Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1812060..1812562 Replicon chromosome
Accession NZ_OW967795
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LQ148_RS08495 Protein ID WP_230158846.1
Coordinates 1812308..1812562 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag LQ148_RS08490 Protein ID WP_001259253.1
Coordinates 1812060..1812311 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS08465 (1807238) 1807238..1808305 - 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LQ148_RS08470 (1808305) 1808305..1809375 - 1071 WP_001524973.1 histidinol-phosphate transaminase -
LQ148_RS08475 (1809372) 1809372..1810676 - 1305 WP_001524971.1 histidinol dehydrogenase -
LQ148_RS08480 (1810682) 1810682..1811581 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
LQ148_RS08485 (1811727) 1811727..1811777 - 51 WP_001364200.1 his operon leader peptide -
LQ148_RS08490 (1812060) 1812060..1812311 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LQ148_RS08495 (1812308) 1812308..1812562 + 255 WP_230158846.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LQ148_RS08500 (1812645) 1812645..1813469 + 825 WP_000754733.1 SDR family oxidoreductase -
LQ148_RS08505 (1813515) 1813515..1814444 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LQ148_RS08510 (1814659) 1814659..1814721 + 63 WP_010723108.1 membrane protein YoeI -
LQ148_RS08515 (1814711) 1814711..1816069 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -
LQ148_RS08520 (1816286) 1816286..1816744 + 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1816286..1816744 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10111.47 Da        Isoelectric Point: 7.2749

>T295829 WP_230158846.1 NZ_OW967795:1812308-1812562 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRNTEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT295829 WP_001259253.1 NZ_OW967795:1812060-1812311 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References