Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1175580..1176307 | Replicon | chromosome |
Accession | NZ_OW967388 | ||
Organism | Enterobacter cloacae isolate 114 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A8B3V067 |
Locus tag | LQ218_RS05550 | Protein ID | WP_022650547.1 |
Coordinates | 1175996..1176307 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A8B3V464 |
Locus tag | LQ218_RS05545 | Protein ID | WP_022650546.1 |
Coordinates | 1175580..1175999 (-) | Length | 140 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LQ218_RS05530 (AI2624V1_1074) | 1172652..1173773 | - | 1122 | WP_003858868.1 | YbdK family carboxylate-amine ligase | - |
LQ218_RS05535 (AI2624V1_1075) | 1173879..1174769 | + | 891 | WP_022650544.1 | oxidoreductase | - |
LQ218_RS05540 (AI2624V1_1076) | 1174822..1175256 | - | 435 | WP_022650545.1 | hypothetical protein | - |
LQ218_RS05545 (AI2624V1_1077) | 1175580..1175999 | - | 420 | WP_022650546.1 | helix-turn-helix domain-containing protein | Antitoxin |
LQ218_RS05550 | 1175996..1176307 | - | 312 | WP_022650547.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
LQ218_RS05555 (AI2624V1_1078) | 1176763..1177419 | + | 657 | WP_022650548.1 | hypothetical protein | - |
LQ218_RS05560 (AI2624V1_1079) | 1177532..1177987 | - | 456 | WP_022650549.1 | hypothetical protein | - |
LQ218_RS05565 (AI2624V1_1080) | 1178270..1179151 | - | 882 | WP_022650550.1 | LysR family transcriptional regulator | - |
LQ218_RS05570 (AI2624V1_1081) | 1179257..1180036 | + | 780 | WP_003858848.1 | acetolactate decarboxylase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12554.34 Da Isoelectric Point: 9.9435
>T295803 WP_022650547.1 NZ_OW967388:c1176307-1175996 [Enterobacter cloacae]
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPSPDEMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKF
FIKHISTHAEYDKLTDYYRRTKE
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPSPDEMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKF
FIKHISTHAEYDKLTDYYRRTKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15447.51 Da Isoelectric Point: 4.6051
>AT295803 WP_022650546.1 NZ_OW967388:c1175999-1175580 [Enterobacter cloacae]
MNYAAAIKAANALTNELPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVEMLTAKIDKYENESPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN
MNYAAAIKAANALTNELPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVEMLTAKIDKYENESPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B3V067 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B3V464 |