295775

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 365931..366597 Replicon chromosome
Accession NZ_OW967263
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5Q945
Locus tag LQ176_RS01700 Protein ID WP_003847996.1
Coordinates 366280..366597 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag LQ176_RS01695 Protein ID WP_003837894.1
Coordinates 365931..366227 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ176_RS01680 (363107) 363107..363580 - 474 WP_003023524.1 transcription elongation factor GreB -
LQ176_RS01685 (363806) 363806..364525 + 720 WP_001157751.1 two-component system response regulator OmpR -
LQ176_RS01690 (364522) 364522..365874 + 1353 WP_003837891.1 two-component system sensor histidine kinase EnvZ -
LQ176_RS01695 (365931) 365931..366227 - 297 WP_003837894.1 NadS family protein Antitoxin
LQ176_RS01700 (366280) 366280..366597 - 318 WP_003847996.1 hypothetical protein Toxin
LQ176_RS01705 (366720) 366720..368342 - 1623 WP_044701411.1 phosphoenolpyruvate carboxykinase (ATP) -
LQ176_RS01710 (368721) 368721..370439 + 1719 WP_047715944.1 DUF4153 domain-containing protein -
LQ176_RS01715 (370549) 370549..371427 - 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12225.15 Da        Isoelectric Point: 10.0909

>T295775 WP_003847996.1 NZ_OW967263:c366597-366280 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT295775 WP_003837894.1 NZ_OW967263:c366227-365931 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5Q945

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References