Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4659298..4659900 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag LQ124_RS22115 Protein ID WP_000897305.1
Coordinates 4659589..4659900 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ124_RS22110 Protein ID WP_000356395.1
Coordinates 4659298..4659588 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS22075 (4654921) 4654921..4655823 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
LQ124_RS22080 (4655820) 4655820..4656455 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
LQ124_RS22085 (4656452) 4656452..4657381 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
LQ124_RS22090 (4657563) 4657563..4657805 - 243 WP_001306649.1 protein YiiF -
LQ124_RS22095 (4658024) 4658024..4658242 - 219 WP_001295676.1 CopG family transcriptional regulator -
LQ124_RS22100 (4658661) 4658661..4658939 - 279 WP_001306650.1 hypothetical protein -
LQ124_RS22105 (4659001) 4659001..4659213 - 213 WP_001590960.1 hypothetical protein -
LQ124_RS22110 (4659298) 4659298..4659588 - 291 WP_000356395.1 NadS family protein Antitoxin
LQ124_RS22115 (4659589) 4659589..4659900 - 312 WP_000897305.1 hypothetical protein Toxin
LQ124_RS22120 (4660129) 4660129..4661037 + 909 WP_001306651.1 alpha/beta hydrolase -
LQ124_RS22125 (4661206) 4661206..4662120 - 915 WP_175085386.1 transposase -
LQ124_RS22130 (4662133) 4662133..4663020 - 888 Protein_4328 hypothetical protein -
LQ124_RS22135 (4663435) 4663435..4664376 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LQ124_RS22140 (4664421) 4664421..4664858 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T295771 WP_000897305.1 NZ_OW967178:c4659900-4659589 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT295771 WP_000356395.1 NZ_OW967178:c4659588-4659298 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References