Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1911801..1912303 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag LQ124_RS09005 Protein ID WP_000767820.1
Coordinates 1912049..1912303 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LQ124_RS09000 Protein ID WP_001259255.1
Coordinates 1911801..1912052 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS08975 (1906979) 1906979..1908046 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LQ124_RS08980 (1908046) 1908046..1909116 - 1071 WP_001590288.1 histidinol-phosphate transaminase -
LQ124_RS08985 (1909113) 1909113..1910417 - 1305 WP_001578572.1 histidinol dehydrogenase -
LQ124_RS08990 (1910423) 1910423..1911322 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
LQ124_RS08995 (1911468) 1911468..1911518 - 51 WP_001364200.1 his operon leader peptide -
LQ124_RS09000 (1911801) 1911801..1912052 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LQ124_RS09005 (1912049) 1912049..1912303 + 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LQ124_RS09010 (1912386) 1912386..1913210 + 825 WP_000754756.1 SDR family oxidoreductase -
LQ124_RS09015 (1913256) 1913256..1914185 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
LQ124_RS09020 (1914400) 1914400..1914462 + 63 WP_010723108.1 membrane protein YoeI -
LQ124_RS09025 (1914452) 1914452..1915810 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
LQ124_RS09030 (1915989) 1915989..1917047 + 1059 WP_001759318.1 thiosulfate utilization transporter TsuA/YeeE -
LQ124_RS09035 (1917061) 1917061..1917288 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T295758 WP_000767820.1 NZ_OW967178:1912049-1912303 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT295758 WP_001259255.1 NZ_OW967178:1911801-1912052 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References