Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 623340..624139 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag LQ124_RS02990 Protein ID WP_000347273.1
Coordinates 623340..623804 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0YUB5
Locus tag LQ124_RS02995 Protein ID WP_001309780.1
Coordinates 623804..624139 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS02960 (618341) 618341..618775 - 435 WP_000948818.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LQ124_RS02965 (618793) 618793..619671 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ124_RS02970 (619661) 619661..620440 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ124_RS02975 (620451) 620451..620924 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ124_RS02980 (620947) 620947..622227 - 1281 WP_000681959.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ124_RS02985 (622476) 622476..623285 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
LQ124_RS02990 (623340) 623340..623804 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ124_RS02995 (623804) 623804..624139 - 336 WP_001309780.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ124_RS03000 (624288) 624288..625859 - 1572 WP_001273738.1 galactarate dehydratase -
LQ124_RS03005 (626234) 626234..627568 + 1335 WP_000599654.1 galactarate/glucarate/glycerate transporter GarP -
LQ124_RS03010 (627584) 627584..628354 + 771 WP_001590759.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T295755 WP_000347273.1 NZ_OW967178:c623804-623340 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12345.94 Da        Isoelectric Point: 4.8616

>AT295755 WP_001309780.1 NZ_OW967178:c624139-623804 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNT
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB V0YUB5

References