Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3875162..3875961 Replicon chromosome
Accession NZ_OW967003
Organism Escherichia coli isolate 624

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag LQ179_RS18620 Protein ID WP_000347273.1
Coordinates 3875162..3875626 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag LQ179_RS18625 Protein ID WP_001308975.1
Coordinates 3875626..3875961 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ179_RS18590 (3870163) 3870163..3870597 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LQ179_RS18595 (3870615) 3870615..3871493 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ179_RS18600 (3871483) 3871483..3872262 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ179_RS18605 (3872273) 3872273..3872746 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ179_RS18610 (3872769) 3872769..3874049 - 1281 WP_023908831.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ179_RS18615 (3874298) 3874298..3875107 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ179_RS18620 (3875162) 3875162..3875626 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ179_RS18625 (3875626) 3875626..3875961 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ179_RS18630 (3876110) 3876110..3877681 - 1572 WP_023908830.1 galactarate dehydratase -
LQ179_RS18635 (3878056) 3878056..3879390 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
LQ179_RS18640 (3879406) 3879406..3880176 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T295746 WP_000347273.1 NZ_OW967003:c3875626-3875162 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT295746 WP_001308975.1 NZ_OW967003:c3875961-3875626 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References