Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 1844827..1845506 Replicon chromosome
Accession NZ_OW967003
Organism Escherichia coli isolate 624

Toxin (Protein)


Gene name higB Uniprot ID A0A0A1A1R1
Locus tag LQ179_RS08990 Protein ID WP_000057541.1
Coordinates 1845204..1845506 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag LQ179_RS08985 Protein ID WP_000806442.1
Coordinates 1844827..1845168 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ179_RS08975 (1841070) 1841070..1842002 - 933 WP_000883035.1 glutaminase A -
LQ179_RS08980 (1842265) 1842265..1844769 + 2505 WP_077737757.1 copper-exporting P-type ATPase CopA -
LQ179_RS08985 (1844827) 1844827..1845168 - 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
LQ179_RS08990 (1845204) 1845204..1845506 - 303 WP_000057541.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ179_RS08995 (1845639) 1845639..1846433 + 795 WP_000365164.1 TraB/GumN family protein -
LQ179_RS09000 (1846637) 1846637..1847116 + 480 WP_000186627.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
LQ179_RS09005 (1847153) 1847153..1848805 - 1653 Protein_1769 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
LQ179_RS09010 (1849023) 1849023..1850243 + 1221 WP_001251634.1 fosmidomycin MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11795.37 Da        Isoelectric Point: 10.2638

>T295738 WP_000057541.1 NZ_OW967003:c1845506-1845204 [Escherichia coli]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT295738 WP_000806442.1 NZ_OW967003:c1845168-1844827 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A1R1

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References