Detailed information of TA system TA029573

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2086612..2086919
• Replicon: chromosome
• Accession: NC_021554
• Organism: Staphylococcus aureus CA-347

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CA347_RS15125
• Protein ID: WP_011447039.1
• Coordinates: 2086743..2086919 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2086612..2086751 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA347_RS10485	2081952..2082212	+	261	WP_001791826.1	hypothetical protein	-
CA347_RS10490	2082265..2082615	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CA347_RS10495	2083299..2083748	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CA347_RS15480	2083843..2084178	-	336	Protein_2001	SH3 domain-containing protein	-
CA347_RS10505	2084828..2085319	-	492	WP_000919350.1	staphylokinase	-
CA347_RS10510	2085510..2086265	-	756	WP_000861038.1	CHAP domain-containing protein	-
CA347_RS10515	2086277..2086531	-	255	WP_000611509.1	phage holin	-
CA347_RS10520	2086583..2086690	+	108	WP_001791821.1	hypothetical protein	-
-	2086612..2086751	+	140	NuclAT_0	-	Antitoxin
-	2086612..2086751	+	140	NuclAT_0	-	Antitoxin
-	2086612..2086751	+	140	NuclAT_0	-	Antitoxin
-	2086612..2086751	+	140	NuclAT_0	-	Antitoxin
CA347_RS15125	2086743..2086919	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CA347_RS10530	2087069..2087365	-	297	Protein_2007	DUF2951 domain-containing protein	-
CA347_RS10535	2087423..2087710	-	288	WP_001040261.1	hypothetical protein	-
CA347_RS10540	2087757..2087909	-	153	WP_001153681.1	hypothetical protein	-
CA347_RS10545	2087899..2091684	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2082265..2133774	51509

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T29573 WP_011447039.1 NC_021554:c2086919-2086743 [Staphylococcus aureus CA-347]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T29573 NC_021554:c2086919-2086743 [Staphylococcus aureus CA-347]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT29573 NC_021554:2086612-2086751 [Staphylococcus aureus CA-347]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin