Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4609801..4610403 Replicon chromosome
Accession NZ_OW849377
Organism Escherichia coli isolate 162

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag LQ158_RS22160 Protein ID WP_000897305.1
Coordinates 4610092..4610403 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ158_RS22155 Protein ID WP_000356397.1
Coordinates 4609801..4610091 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ158_RS22130 (4605727) 4605727..4606629 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
LQ158_RS22135 (4606626) 4606626..4607261 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
LQ158_RS22140 (4607258) 4607258..4608187 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
LQ158_RS22145 (4608517) 4608517..4608759 - 243 WP_001086388.1 protein YiiF -
LQ158_RS22150 (4608978) 4608978..4609196 - 219 WP_001295676.1 CopG family transcriptional regulator -
LQ158_RS22155 (4609801) 4609801..4610091 - 291 WP_000356397.1 NadS family protein Antitoxin
LQ158_RS22160 (4610092) 4610092..4610403 - 312 WP_000897305.1 hypothetical protein Toxin
LQ158_RS22165 (4610632) 4610632..4611540 + 909 WP_001162704.1 alpha/beta hydrolase -
LQ158_RS22170 (4611604) 4611604..4612545 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LQ158_RS22175 (4612590) 4612590..4613027 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
LQ158_RS22180 (4613024) 4613024..4613896 - 873 WP_000920762.1 virulence factor BrkB family protein -
LQ158_RS22185 (4613890) 4613890..4614489 - 600 WP_001295269.1 glucose-1-phosphatase -
LQ158_RS22190 (4614588) 4614588..4615373 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T295693 WP_000897305.1 NZ_OW849377:c4610403-4610092 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT295693 WP_000356397.1 NZ_OW849377:c4610091-4609801 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References