Detailed information of TA system TA029568

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1573232..1573811
• Replicon: chromosome
• Accession: NC_021554
• Organism: Staphylococcus aureus CA-347

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CA347_RS07625
• Protein ID: WP_001025401.1
• Coordinates: 1573566..1573811 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1573232..1573597 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA347_RS07585	1569975..1570532	-	558	WP_016528725.1	DUF2815 family protein	-
CA347_RS07590	1570558..1571724	-	1167	WP_015581855.1	DUF2800 domain-containing protein	-
CA347_RS07595	1571721..1572083	-	363	WP_000985986.1	hypothetical protein	-
CA347_RS07600	1572098..1572421	-	324	WP_000175000.1	hypothetical protein	-
CA347_RS07605	1572500..1572661	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
CA347_RS07610	1572674..1572937	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CA347_RS07615	1572962..1573177	-	216	WP_001097552.1	hypothetical protein	-
CA347_RS07620	1573232..1573597	+	366	WP_001128433.1	hypothetical protein	Antitoxin
CA347_RS07625	1573566..1573811	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CA347_RS07630	1573878..1574258	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
CA347_RS07635	1574245..1574442	-	198	WP_001148860.1	hypothetical protein	-
CA347_RS07640	1574512..1574724	+	213	WP_000362644.1	hypothetical protein	-
CA347_RS15580	1574765..1574914	-	150	WP_000771849.1	hypothetical protein	-
CA347_RS07645	1574929..1575372	-	444	WP_000435357.1	hypothetical protein	-
CA347_RS07650	1575420..1575632	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
CA347_RS07655	1575784..1576515	+	732	WP_000511090.1	XRE family transcriptional regulator	-
CA347_RS07660	1576586..1576768	+	183	WP_000705240.1	hypothetical protein	-
CA347_RS07665	1576805..1576951	+	147	WP_001794606.1	hypothetical protein	-
CA347_RS07670	1576948..1577562	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1532474..1590884	58410

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T29568 WP_001025401.1 NC_021554:c1573811-1573566 [Staphylococcus aureus CA-347]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T29568 NC_021554:c1573811-1573566 [Staphylococcus aureus CA-347]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT29568 NC_021554:1573232-1573597 [Staphylococcus aureus CA-347]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin