Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1249623..1250272 Replicon chromosome
Accession NZ_OW849195
Organism Enterobacter cloacae isolate 125

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LQ145_RS06170 Protein ID WP_023332294.1
Coordinates 1249910..1250272 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2W0GCS7
Locus tag LQ145_RS06165 Protein ID WP_014882863.1
Coordinates 1249623..1249922 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ145_RS06155 (AI2762V1_1198) 1246048..1248021 + 1974 WP_023332292.1 PhoX family phosphatase -
LQ145_RS06160 (AI2762V1_1199) 1248124..1249512 + 1389 WP_023332293.1 phenylalanine transporter -
LQ145_RS06165 (AI2762V1_1200) 1249623..1249922 - 300 WP_014882863.1 helix-turn-helix transcriptional regulator Antitoxin
LQ145_RS06170 (AI2762V1_1201) 1249910..1250272 - 363 WP_023332294.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ145_RS06175 (AI2762V1_1202) 1250478..1251713 + 1236 WP_023332295.1 MFS transporter -
LQ145_RS06180 (AI2762V1_1203) 1251729..1252754 + 1026 WP_023332296.1 sugar phosphate isomerase/epimerase -
LQ145_RS06185 (AI2762V1_1204) 1252747..1253889 + 1143 WP_023332297.1 Gfo/Idh/MocA family oxidoreductase -
LQ145_RS06190 (AI2762V1_1205) 1253965..1254936 + 972 WP_014882868.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13953.90 Da        Isoelectric Point: 6.2260

>T295666 WP_023332294.1 NZ_OW849195:c1250272-1249910 [Enterobacter cloacae]
MWNVETTDRFDQWYFEQTTALKEDVLAMMHILAEFGPTLGRPYVDTVKASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10860.61 Da        Isoelectric Point: 9.8627

>AT295666 WP_014882863.1 NZ_OW849195:c1249922-1249623 [Enterobacter cloacae]
MATLKELMAQQSAESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0GCS7

References