Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 101070..101339 Replicon plasmid P1
Accession NZ_OW849065
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag LQ135_RS26175 Protein ID WP_001372321.1
Coordinates 101214..101339 (+) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 101070..101135 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS26140 96905..97390 + 486 WP_042029316.1 single-stranded DNA-binding protein -
LQ135_RS26145 97446..97679 + 234 WP_000006004.1 DUF905 domain-containing protein -
LQ135_RS26150 97738..99696 + 1959 WP_200121858.1 ParB/RepB/Spo0J family partition protein -
LQ135_RS26155 99751..100185 + 435 WP_000845901.1 conjugation system SOS inhibitor PsiB -
LQ135_RS26160 100182..100944 + 763 Protein_119 plasmid SOS inhibition protein A -
LQ135_RS26165 100913..101101 - 189 WP_001299721.1 hypothetical protein -
- 100913..101137 + 225 NuclAT_0 - -
- 100913..101137 + 225 NuclAT_0 - -
- 100913..101137 + 225 NuclAT_0 - -
- 100913..101137 + 225 NuclAT_0 - -
- 101070..101135 - 66 - - Antitoxin
LQ135_RS26170 101123..101272 + 150 Protein_121 plasmid maintenance protein Mok -
LQ135_RS26175 101214..101339 + 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
LQ135_RS26180 101559..101789 + 231 WP_071587244.1 hypothetical protein -
LQ135_RS26185 101787..101960 - 174 Protein_124 hypothetical protein -
LQ135_RS26190 102258..102545 + 288 WP_000107537.1 hypothetical protein -
LQ135_RS26195 102666..103487 + 822 WP_001234469.1 DUF932 domain-containing protein -
LQ135_RS26200 103784..104431 - 648 WP_000614282.1 transglycosylase SLT domain-containing protein -
LQ135_RS26205 104717..105100 + 384 WP_001151564.1 conjugal transfer relaxosome DNA-binding protein TraM -
LQ135_RS26210 105294..105980 + 687 WP_000332487.1 PAS domain-containing protein -
LQ135_RS26215 106074..106301 + 228 WP_001254388.1 conjugal transfer relaxosome protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 / aadA5 / qacE / sul1 - 1..146311 146311


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T295630 WP_001372321.1 NZ_OW849065:101214-101339 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp


Antitoxin


Download         Length: 66 bp

>AT295630 NZ_OW849065:c101135-101070 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References