295624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4725552..4726231 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag LQ135_RS23255 Protein ID WP_000057523.1
Coordinates 4725552..4725854 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag LQ135_RS23260 Protein ID WP_000806442.1
Coordinates 4725890..4726231 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS23230 (4720928) 4720928..4722580 + 1653 WP_000771748.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
LQ135_RS23235 (4722618) 4722618..4723121 - 504 WP_000667000.1 hypothetical protein -
LQ135_RS23240 (4723118) 4723118..4723774 - 657 WP_015674862.1 hypothetical protein -
LQ135_RS23245 (4723942) 4723942..4724421 - 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
LQ135_RS23250 (4724625) 4724625..4725419 - 795 WP_000365147.1 TraB/GumN family protein -
LQ135_RS23255 (4725552) 4725552..4725854 + 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ135_RS23260 (4725890) 4725890..4726231 + 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
LQ135_RS23265 (4726289) 4726289..4728793 - 2505 WP_000083947.1 copper-exporting P-type ATPase CopA -
LQ135_RS23270 (4729055) 4729055..4729987 + 933 WP_000883041.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T295624 WP_000057523.1 NZ_OW849064:4725552-4725854 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT295624 WP_000806442.1 NZ_OW849064:4725890-4726231 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
AlphaFold DB S1QAY3

References