295620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4204915..4205173 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag LQ135_RS20800 Protein ID WP_000809168.1
Coordinates 4204915..4205067 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4205116..4205173 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS20780 4200162..4200875 - 714 WP_001102393.1 acidic protein MsyB -
LQ135_RS20785 4200901..4201305 - 405 WP_000843689.1 DUF2541 family protein -
LQ135_RS20790 4201676..4203592 + 1917 WP_000516135.1 molecular chaperone DnaK -
LQ135_RS20795 4203681..4204811 + 1131 WP_001118464.1 molecular chaperone DnaJ -
LQ135_RS20800 4204915..4205067 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 4205116..4205173 + 58 - - Antitoxin
LQ135_RS20805 4205681..4206442 + 762 WP_001274833.1 outer membrane protein OmpK -
LQ135_RS20810 4206463..4207956 + 1494 WP_001173016.1 sulfatase-like hydrolase/transferase -
LQ135_RS20815 4208085..4209344 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T295620 WP_000809168.1 NZ_OW849064:c4205067-4204915 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT295620 NZ_OW849064:4205116-4205173 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References