295615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3494392..3494994 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag LQ135_RS17310 Protein ID WP_000897302.1
Coordinates 3494392..3494703 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ135_RS17315 Protein ID WP_000356397.1
Coordinates 3494704..3494994 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS17285 (3490306) 3490306..3490905 + 600 WP_001296610.1 glucose-1-phosphatase -
LQ135_RS17290 (3490899) 3490899..3491771 + 873 WP_000920762.1 virulence factor BrkB family protein -
LQ135_RS17295 (3491768) 3491768..3492205 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
LQ135_RS17300 (3492250) 3492250..3493191 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LQ135_RS17305 (3493255) 3493255..3494163 - 909 WP_001385591.1 alpha/beta hydrolase -
LQ135_RS17310 (3494392) 3494392..3494703 + 312 WP_000897302.1 hypothetical protein Toxin
LQ135_RS17315 (3494704) 3494704..3494994 + 291 WP_000356397.1 NadS family protein Antitoxin
LQ135_RS17320 (3495353) 3495353..3495631 + 279 WP_001296612.1 hypothetical protein -
LQ135_RS17325 (3496028) 3496028..3496246 + 219 WP_001251293.1 CopG family transcriptional regulator -
LQ135_RS17330 (3496431) 3496431..3497171 - 741 WP_000608806.1 hypothetical protein -
LQ135_RS17335 (3497196) 3497196..3498044 - 849 WP_001038650.1 hypothetical protein -
LQ135_RS17340 (3498334) 3498334..3498576 + 243 WP_001068514.1 CopG family transcriptional regulator -
LQ135_RS17345 (3498758) 3498758..3499687 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T295615 WP_000897302.1 NZ_OW849064:3494392-3494703 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT295615 WP_000356397.1 NZ_OW849064:3494704-3494994 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References