295612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2614401..2615200 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag LQ135_RS13025 Protein ID WP_000347251.1
Coordinates 2614736..2615200 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag LQ135_RS13020 Protein ID WP_001296435.1
Coordinates 2614401..2614736 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS13005 (2610186) 2610186..2610956 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
LQ135_RS13010 (2610972) 2610972..2612306 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
LQ135_RS13015 (2612681) 2612681..2614252 + 1572 WP_001273763.1 galactarate dehydratase -
LQ135_RS13020 (2614401) 2614401..2614736 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ135_RS13025 (2614736) 2614736..2615200 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ135_RS13030 (2615255) 2615255..2616064 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ135_RS13035 (2616313) 2616313..2617593 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ135_RS13040 (2617616) 2617616..2618089 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ135_RS13045 (2618100) 2618100..2618879 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ135_RS13050 (2618869) 2618869..2619747 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ135_RS13055 (2619765) 2619765..2620199 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T295612 WP_000347251.1 NZ_OW849064:2614736-2615200 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT295612 WP_001296435.1 NZ_OW849064:2614401-2614736 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References