Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1325223..1325725 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag LQ135_RS07085 Protein ID WP_000767819.1
Coordinates 1325223..1325477 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag LQ135_RS07090 Protein ID WP_001259253.1
Coordinates 1325474..1325725 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS07060 (1321041) 1321041..1321499 - 459 WP_230181294.1 IS200/IS605-like element IS200C family transposase -
LQ135_RS07065 (1321716) 1321716..1323074 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
LQ135_RS07070 (1323064) 1323064..1323126 - 63 WP_010723108.1 membrane protein YoeI -
LQ135_RS07075 (1323341) 1323341..1324270 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LQ135_RS07080 (1324316) 1324316..1325140 - 825 WP_000754737.1 SDR family oxidoreductase -
LQ135_RS07085 (1325223) 1325223..1325477 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LQ135_RS07090 (1325474) 1325474..1325725 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LQ135_RS07095 (1326008) 1326008..1326058 + 51 WP_001364200.1 his operon leader peptide -
LQ135_RS07100 (1326204) 1326204..1327103 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
LQ135_RS07105 (1327109) 1327109..1328413 + 1305 WP_001296211.1 histidinol dehydrogenase -
LQ135_RS07110 (1328410) 1328410..1329480 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
LQ135_RS07115 (1329480) 1329480..1330547 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1321041..1321499 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T295607 WP_000767819.1 NZ_OW849064:c1325477-1325223 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT295607 WP_001259253.1 NZ_OW849064:c1325725-1325474 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References