Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 777672..778365 Replicon chromosome
Accession NZ_OW848980
Organism Escherichia coli isolate 23

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LQ157_RS03795 Protein ID WP_000415584.1
Coordinates 777672..777968 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LQ157_RS03800 Protein ID WP_000650107.1
Coordinates 777970..778365 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ157_RS03765 (773347) 773347..773661 - 315 WP_000958598.1 putative quinol monooxygenase -
LQ157_RS03770 (773692) 773692..774273 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LQ157_RS03775 (774383) 774383..775732 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
LQ157_RS03780 (775729) 775729..776388 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
LQ157_RS03785 (776540) 776540..776932 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LQ157_RS03790 (776985) 776985..777467 + 483 WP_000183494.1 GyrI-like domain-containing protein -
LQ157_RS03795 (777672) 777672..777968 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LQ157_RS03800 (777970) 777970..778365 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LQ157_RS03805 (778498) 778498..780105 + 1608 WP_001701096.1 ABC transporter substrate-binding protein -
LQ157_RS03810 (780243) 780243..782501 + 2259 WP_024249834.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 765944..778365 12421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T295567 WP_000415584.1 NZ_OW848980:777672-777968 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT295567 WP_000650107.1 NZ_OW848980:777970-778365 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References