Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2587193..2587755 Replicon chromosome
Accession NZ_OW848788
Organism Citrobacter freundii isolate 112

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5QCT4
Locus tag LQ087_RS12805 Protein ID WP_003836234.1
Coordinates 2587477..2587755 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B5QC60
Locus tag LQ087_RS12800 Protein ID WP_003836231.1
Coordinates 2587193..2587477 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ087_RS12785 (2584884) 2584884..2585768 + 885 WP_003836226.1 formate dehydrogenase N subunit beta -
LQ087_RS12790 (2585761) 2585761..2586417 + 657 WP_003020054.1 formate dehydrogenase-N subunit gamma -
LQ087_RS12795 (2586547) 2586547..2587149 + 603 WP_054528391.1 inorganic diphosphatase -
LQ087_RS12800 (2587193) 2587193..2587477 - 285 WP_003836231.1 HigA family addiction module antitoxin Antitoxin
LQ087_RS12805 (2587477) 2587477..2587755 - 279 WP_003836234.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ087_RS12810 (2587976) 2587976..2589691 - 1716 WP_230121981.1 ABC-F family ATP-binding cassette domain-containing protein -
LQ087_RS12815 (2590110) 2590110..2591012 + 903 WP_016150253.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10637.28 Da        Isoelectric Point: 9.8965

>T295557 WP_003836234.1 NZ_OW848788:c2587755-2587477 [Citrobacter freundii]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGDRDGIWAIAVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10358.10 Da        Isoelectric Point: 8.8094

>AT295557 WP_003836231.1 NZ_OW848788:c2587477-2587193 [Citrobacter freundii]
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQTTWSLAEAQ
KSVDISRLRKLAVQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5QCT4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5QC60

References