Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 346946..347612 Replicon chromosome
Accession NZ_OW848788
Organism Citrobacter freundii isolate 112

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5Q945
Locus tag LQ087_RS01640 Protein ID WP_003847996.1
Coordinates 347295..347612 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag LQ087_RS01635 Protein ID WP_003837894.1
Coordinates 346946..347242 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ087_RS01615 (342897) 342897..343370 - 474 WP_003023524.1 transcription elongation factor GreB -
LQ087_RS01620 (343632) 343632..344752 + 1121 WP_085950818.1 IS3-like element ISSen4 family transposase -
LQ087_RS01625 (344821) 344821..345540 + 720 WP_001157751.1 two-component system response regulator OmpR -
LQ087_RS01630 (345537) 345537..346889 + 1353 WP_230121619.1 two-component system sensor histidine kinase EnvZ -
LQ087_RS01635 (346946) 346946..347242 - 297 WP_003837894.1 NadS family protein Antitoxin
LQ087_RS01640 (347295) 347295..347612 - 318 WP_003847996.1 hypothetical protein Toxin
LQ087_RS01645 (347735) 347735..349357 - 1623 WP_003023529.1 phosphoenolpyruvate carboxykinase (ATP) -
LQ087_RS01650 (349736) 349736..351454 + 1719 WP_230121620.1 DUF4153 domain-containing protein -
LQ087_RS01655 (351564) 351564..352442 - 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12225.15 Da        Isoelectric Point: 10.0909

>T295550 WP_003847996.1 NZ_OW848788:c347612-347295 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT295550 WP_003837894.1 NZ_OW848788:c347242-346946 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5Q945

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References