295536

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4114986..4115665 Replicon chromosome
Accession NZ_OW848785
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag LQ117_RS19785 Protein ID WP_000057523.1
Coordinates 4114986..4115288 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag LQ117_RS19790 Protein ID WP_000806442.1
Coordinates 4115324..4115665 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ117_RS19760 (4110362) 4110362..4112014 + 1653 WP_000771748.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
LQ117_RS19765 (4112052) 4112052..4112555 - 504 WP_000667000.1 hypothetical protein -
LQ117_RS19770 (4112552) 4112552..4113352 - 801 WP_000439798.1 hypothetical protein -
LQ117_RS19775 (4113376) 4113376..4113855 - 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
LQ117_RS19780 (4114059) 4114059..4114853 - 795 WP_000365147.1 TraB/GumN family protein -
LQ117_RS19785 (4114986) 4114986..4115288 + 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ117_RS19790 (4115324) 4115324..4115665 + 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
LQ117_RS19795 (4115723) 4115723..4118227 - 2505 WP_000083947.1 copper-exporting P-type ATPase CopA -
LQ117_RS19800 (4118489) 4118489..4119421 + 933 WP_000883041.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T295536 WP_000057523.1 NZ_OW848785:4114986-4115288 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT295536 WP_000806442.1 NZ_OW848785:4115324-4115665 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
AlphaFold DB S1QAY3

References