295527

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2881414..2882016 Replicon chromosome
Accession NZ_OW848785
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag LQ117_RS13910 Protein ID WP_000897302.1
Coordinates 2881414..2881725 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ117_RS13915 Protein ID WP_000356397.1
Coordinates 2881726..2882016 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ117_RS13885 (2877328) 2877328..2877927 + 600 WP_001296610.1 glucose-1-phosphatase -
LQ117_RS13890 (2877921) 2877921..2878793 + 873 WP_000920762.1 virulence factor BrkB family protein -
LQ117_RS13895 (2878790) 2878790..2879227 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
LQ117_RS13900 (2879272) 2879272..2880213 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LQ117_RS13905 (2880277) 2880277..2881185 - 909 WP_001385591.1 alpha/beta hydrolase -
LQ117_RS13910 (2881414) 2881414..2881725 + 312 WP_000897302.1 hypothetical protein Toxin
LQ117_RS13915 (2881726) 2881726..2882016 + 291 WP_000356397.1 NadS family protein Antitoxin
LQ117_RS13920 (2882375) 2882375..2882653 + 279 WP_001296612.1 hypothetical protein -
LQ117_RS13925 (2883050) 2883050..2883268 + 219 WP_001251293.1 CopG family transcriptional regulator -
LQ117_RS13930 (2883453) 2883453..2884193 - 741 WP_000608806.1 hypothetical protein -
LQ117_RS13935 (2884218) 2884218..2885066 - 849 WP_001038650.1 hypothetical protein -
LQ117_RS13940 (2885356) 2885356..2885598 + 243 WP_001068514.1 CopG family transcriptional regulator -
LQ117_RS13945 (2885780) 2885780..2886709 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T295527 WP_000897302.1 NZ_OW848785:2881414-2881725 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT295527 WP_000356397.1 NZ_OW848785:2881726-2882016 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References