295525

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2072188..2072987 Replicon chromosome
Accession NZ_OW848785
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag LQ117_RS09955 Protein ID WP_000347251.1
Coordinates 2072523..2072987 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag LQ117_RS09950 Protein ID WP_001296435.1
Coordinates 2072188..2072523 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ117_RS09935 (2067973) 2067973..2068743 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
LQ117_RS09940 (2068759) 2068759..2070093 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
LQ117_RS09945 (2070468) 2070468..2072039 + 1572 WP_001273763.1 galactarate dehydratase -
LQ117_RS09950 (2072188) 2072188..2072523 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ117_RS09955 (2072523) 2072523..2072987 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ117_RS09960 (2073042) 2073042..2073851 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ117_RS09965 (2074100) 2074100..2075380 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ117_RS09970 (2075403) 2075403..2075876 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ117_RS09975 (2075887) 2075887..2076666 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ117_RS09980 (2076656) 2076656..2077534 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ117_RS09985 (2077552) 2077552..2077986 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T295525 WP_000347251.1 NZ_OW848785:2072523-2072987 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT295525 WP_001296435.1 NZ_OW848785:2072188-2072523 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References