295524

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2030480..2031207 Replicon chromosome
Accession NZ_OW848785
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag LQ117_RS09725 Protein ID WP_000550189.1
Coordinates 2030893..2031207 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ117_RS09720 Protein ID WP_000560269.1
Coordinates 2030480..2030896 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ117_RS09710 (2025840) 2025840..2028191 + 2352 WP_000695432.1 alpha-glucosidase -
LQ117_RS09715 (2028417) 2028417..2030435 + 2019 WP_000121413.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
LQ117_RS09720 (2030480) 2030480..2030896 - 417 WP_000560269.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
LQ117_RS09725 (2030893) 2030893..2031207 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
LQ117_RS09730 (2031492) 2031492..2032628 - 1137 WP_000018703.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
LQ117_RS09735 (2032713) 2032713..2033216 + 504 WP_001295542.1 M48 family metallopeptidase -
LQ117_RS09740 (2033293) 2033293..2033985 + 693 WP_000942551.1 vancomycin high temperature exclusion protein -
LQ117_RS09745 (2034064) 2034064..2035050 + 987 WP_001385498.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T295524 WP_000550189.1 NZ_OW848785:c2031207-2030893 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15023.47 Da        Isoelectric Point: 4.4547

>AT295524 WP_000560269.1 NZ_OW848785:c2030896-2030480 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFVEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References