Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 787181..787683 Replicon chromosome
Accession NZ_OW848785
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag LQ117_RS04025 Protein ID WP_000767819.1
Coordinates 787181..787435 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag LQ117_RS04030 Protein ID WP_001259253.1
Coordinates 787432..787683 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ117_RS04000 (782999) 782999..783457 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
LQ117_RS04005 (783674) 783674..785032 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
LQ117_RS04010 (785022) 785022..785084 - 63 WP_010723108.1 membrane protein YoeI -
LQ117_RS04015 (785299) 785299..786228 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LQ117_RS04020 (786274) 786274..787098 - 825 WP_000754737.1 SDR family oxidoreductase -
LQ117_RS04025 (787181) 787181..787435 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LQ117_RS04030 (787432) 787432..787683 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LQ117_RS04035 (787966) 787966..788016 + 51 WP_001364200.1 his operon leader peptide -
LQ117_RS04040 (788162) 788162..789061 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
LQ117_RS04045 (789067) 789067..790371 + 1305 WP_001296211.1 histidinol dehydrogenase -
LQ117_RS04050 (790368) 790368..791438 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
LQ117_RS04055 (791438) 791438..792505 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 782999..783457 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T295521 WP_000767819.1 NZ_OW848785:c787435-787181 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT295521 WP_001259253.1 NZ_OW848785:c787683-787432 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References