Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3624827..3625581 Replicon chromosome
Accession NZ_OW706648
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name higB Uniprot ID Q8Z2U0
Locus tag NBW98_RS17965 Protein ID WP_000558160.1
Coordinates 3624827..3625138 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBW98_RS17970 Protein ID WP_001259009.1
Coordinates 3625135..3625581 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW98_RS17935 3620493..3621395 + 903 WP_000331359.1 formate dehydrogenase subunit beta -
NBW98_RS17940 3621392..3622027 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NBW98_RS17945 3622024..3622953 + 930 WP_000027727.1 formate dehydrogenase accessory protein FdhE -
NBW98_RS17950 3622991..3623365 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin -
NBW98_RS17955 3623365..3623607 - 243 WP_001523745.1 CopG family transcriptional regulator -
NBW98_RS17960 3623812..3624741 + 930 WP_001162859.1 alpha/beta hydrolase -
NBW98_RS17965 3624827..3625138 + 312 WP_000558160.1 type II toxin-antitoxin system HigB family toxin Toxin
NBW98_RS17970 3625135..3625581 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
NBW98_RS17975 3625596..3626537 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NBW98_RS17980 3626582..3627019 - 438 WP_000560975.1 D-aminoacyl-tRNA deacylase -
NBW98_RS17985 3627016..3627888 - 873 WP_000921423.1 virulence factor BrkB family protein -
NBW98_RS17990 3627882..3628481 - 600 WP_000965695.1 glucose-1-phosphatase -
NBW98_RS17995 3628672..3629475 - 804 WP_000059689.1 DeoR family transcriptional regulator -
NBW98_RS18000 3629509..3630405 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12449.38 Da        Isoelectric Point: 8.4020

>T295493 WP_000558160.1 NZ_OW706648:3624827-3625138 [Salmonella enterica subsp. enterica serovar Typhi]
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE

Download         Length: 312 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT295493 WP_001259009.1 NZ_OW706648:3625135-3625581 [Salmonella enterica subsp. enterica serovar Typhi]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714FUZ5

Antitoxin

Source ID Structure

References