Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1900210..1900859 Replicon chromosome
Accession NC_021500
Organism Enterobacter sp. R4-368

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H650_RS08935 Protein ID WP_020454951.1
Coordinates 1900497..1900859 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H650_RS08930 Protein ID WP_020454950.1
Coordinates 1900210..1900509 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H650_RS08910 1895913..1897739 + 1827 WP_020454946.1 glycoside hydrolase family 15 protein -
H650_RS08915 1897813..1898865 - 1053 WP_020454947.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
H650_RS08920 1898849..1899616 - 768 WP_020454948.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
H650_RS25710 1899885..1900082 + 198 WP_189660102.1 hypothetical protein -
H650_RS08930 1900210..1900509 - 300 WP_020454950.1 helix-turn-helix domain-containing protein Antitoxin
H650_RS08935 1900497..1900859 - 363 WP_020454951.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H650_RS08940 1900966..1901673 - 708 WP_020454952.1 winged helix-turn-helix domain-containing protein -
H650_RS08945 1901670..1902062 - 393 WP_020454953.1 hypothetical protein -
H650_RS08950 1902064..1902378 - 315 WP_020454954.1 antibiotic biosynthesis monooxygenase -
H650_RS08955 1902610..1904469 + 1860 WP_044489715.1 beta-glucoside-specific PTS transporter subunit IIABC -
H650_RS08960 1904509..1905513 + 1005 WP_020454956.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-84)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14006.08 Da        Isoelectric Point: 7.9470

>T29544 WP_020454951.1 NC_021500:c1900859-1900497 [Enterobacter sp. R4-368]
MWQVITTERFDVWFSIQPELLQDEVLAVFRILSEFGPQLGRPYVDTVKGSTYSNLKELRIQYAGSPVRAFFAFDSTRRAI
VLCAGDKTGVNEKRFYKEMIKIADAEFKNYIQNKELTWQP

Download         Length: 363 bp

>T29544 NC_021500:c1900859-1900497 [Enterobacter sp. R4-368]
ATGTGGCAAGTGATTACGACGGAGCGTTTTGATGTGTGGTTTAGCATCCAGCCAGAACTGTTGCAGGATGAGGTTTTAGC
GGTTTTCAGGATCCTGAGTGAGTTTGGCCCGCAGCTTGGGCGCCCCTATGTTGATACTGTAAAAGGATCAACCTATAGCA
ATTTGAAAGAGTTGAGGATCCAGTATGCAGGTTCTCCCGTTCGCGCCTTTTTTGCGTTCGATTCTACGCGGCGGGCTATT
GTGTTGTGCGCCGGAGATAAAACGGGCGTTAACGAGAAACGATTTTATAAAGAGATGATAAAAATTGCCGACGCAGAGTT
CAAAAATTATATTCAAAATAAGGAGTTAACGTGGCAACCTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10974.62 Da        Isoelectric Point: 8.6587

>AT29544 WP_020454950.1 NC_021500:c1900509-1900210 [Enterobacter sp. R4-368]
VATLDDLLAKRSPESQARIEERVNELRRNIVLSQLREELNISQTELAGVMGVKQPTLAKIEQPGNDPRLSTLKRYVSALG
GELSIDITLPTGKRVAFHI

Download         Length: 300 bp

>AT29544 NC_021500:c1900509-1900210 [Enterobacter sp. R4-368]
GTGGCAACCTTAGACGACCTTTTAGCGAAACGCAGCCCTGAAAGCCAGGCGCGAATTGAAGAGCGTGTTAATGAGCTGCG
CCGCAACATTGTATTGAGCCAGCTACGTGAAGAATTGAATATTTCCCAGACCGAGCTTGCCGGAGTCATGGGCGTCAAAC
AGCCGACACTGGCGAAGATAGAGCAGCCTGGCAACGATCCCCGTCTCTCTACTCTCAAGCGCTATGTCTCTGCGTTAGGC
GGTGAGTTAAGCATTGATATCACATTGCCGACGGGTAAACGCGTTGCATTTCATATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References