295348

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2162674..2163542 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag MR179_RS10190 Protein ID WP_010886136.1
Coordinates 2163165..2163542 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag MR179_RS10185 Protein ID WP_003409886.1
Coordinates 2162674..2163123 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS10145 2158459..2159679 + 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
MR179_RS10150 2159712..2159984 + 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR179_RS10155 2159988..2160395 + 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
MR179_RS10160 2160555..2161049 - 495 WP_003899099.1 hypothetical protein -
MR179_RS10165 2161036..2161287 + 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
MR179_RS10170 2161284..2161580 + 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
MR179_RS10175 2161629..2162243 + 615 WP_003901296.1 hypothetical protein -
MR179_RS10180 2162132..2162677 - 546 WP_003409891.1 SecB-like chaperone -
MR179_RS10185 2162674..2163123 - 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
MR179_RS10190 2163165..2163542 - 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
MR179_RS10195 2163517..2164038 + 522 WP_003904745.1 hypothetical protein -
MR179_RS10200 2164012..2164323 - 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
MR179_RS10205 2164320..2164535 - 216 WP_003409878.1 antitoxin -
MR179_RS10210 2164775..2165071 + 297 WP_003409877.1 hypothetical protein -
MR179_RS10215 2165072..2165263 + 192 WP_003409876.1 hypothetical protein -
MR179_RS10220 2165284..2166186 + 903 WP_031657727.1 hypothetical protein -
MR179_RS10225 2166197..2166547 + 351 WP_003899096.1 hypothetical protein -
MR179_RS10230 2166661..2166843 + 183 WP_003409870.1 hypothetical protein -
MR179_RS10235 2166836..2167237 - 402 WP_003409869.1 hypothetical protein -
MR179_RS10240 2167301..2167753 + 453 WP_003899095.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T295348 WP_010886136.1 NZ_OW052571:c2163542-2163165 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT295348 WP_003409886.1 NZ_OW052571:c2163123-2162674 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References