Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 816434..817104 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag MR179_RS03655 Protein ID WP_003899954.1
Coordinates 816760..817104 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag MR179_RS03650 Protein ID WP_003899955.1
Coordinates 816434..816763 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS03625 811849..812883 + 1035 WP_003416786.1 IS30 family transposase -
MR179_RS03630 813130..813339 - 210 WP_003416778.1 hypothetical protein -
MR179_RS03635 813507..814772 + 1266 WP_003912135.1 hypothetical protein -
MR179_RS03640 814932..815552 - 621 WP_003899957.1 RES family NAD+ phosphorylase -
MR179_RS03645 815549..815896 - 348 WP_003899956.1 DUF2384 domain-containing protein -
MR179_RS03650 816434..816763 - 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
MR179_RS03655 816760..817104 - 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MR179_RS03660 817335..817787 + 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR179_RS03665 817790..818224 + 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
MR179_RS03675 819929..821218 - 1290 WP_003416640.1 ATP-binding protein -
MR179_RS03680 821506..821799 - 294 WP_003416635.1 hypothetical protein -
MR179_RS03685 821812..822023 - 212 Protein_730 (R)-hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T295324 WP_003899954.1 NZ_OW052571:c817104-816760 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT295324 WP_003899955.1 NZ_OW052571:c816763-816434 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
PDB 6LTY
PDB 6LTZ
AlphaFold DB G0THF6

References