295319

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4397342..4398261 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag MR177_RS20485 Protein ID WP_242302828.1
Coordinates 4397342..4397947 (+) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag MR177_RS20490 Protein ID WP_003410124.1
Coordinates 4397956..4398261 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS20465 4394830..4395726 + 897 WP_003904759.1 hypothetical protein -
MR177_RS20470 4395933..4396169 + 237 WP_003410133.1 hypothetical protein -
MR177_RS20475 4396208..4396798 + 591 WP_057145698.1 hypothetical protein -
MR177_RS20480 4396958..4397317 + 360 WP_003410131.1 hypothetical protein -
MR177_RS20485 4397342..4397947 + 606 WP_242302828.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MR177_RS20490 4397956..4398261 + 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
MR177_RS20495 4398346..4398645 + 300 WP_003410120.1 hypothetical protein -
MR177_RS20500 4398661..4399077 - 417 WP_003410114.1 hypothetical protein -
MR177_RS20505 4399067..4399786 - 720 WP_003410108.1 DUF433 domain-containing protein -
MR177_RS20510 4400028..4401068 - 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
MR177_RS20515 4401065..4401640 - 576 WP_003410100.1 hypothetical protein -
MR177_RS20520 4401994..4403250 + 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22773.01 Da        Isoelectric Point: 7.3073

>T295319 WP_242302828.1 NZ_OW052570:4397342-4397947 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPVRQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT295319 WP_003410124.1 NZ_OW052570:4397956-4398261 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BV30

References