295302

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3115727..3116397 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag MR177_RS14385 Protein ID WP_003899954.1
Coordinates 3116053..3116397 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag MR177_RS14380 Protein ID WP_003899955.1
Coordinates 3115727..3116056 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS14355 3111142..3112176 + 1035 WP_003905011.1 IS30 family transposase -
MR177_RS14360 3112423..3112632 - 210 WP_003416778.1 hypothetical protein -
MR177_RS14365 3112800..3114065 + 1266 WP_003909837.1 hypothetical protein -
MR177_RS14370 3114225..3114845 - 621 WP_003899957.1 RES family NAD+ phosphorylase -
MR177_RS14375 3114842..3115189 - 348 WP_003899956.1 DUF2384 domain-containing protein -
MR177_RS14380 3115727..3116056 - 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
MR177_RS14385 3116053..3116397 - 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MR177_RS14390 3116628..3117080 + 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR177_RS14395 3117083..3117517 + 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
MR177_RS14400 3117864..3119153 - 1290 WP_003416640.1 ATP-binding protein -
MR177_RS14405 3119441..3119734 - 294 WP_003416635.1 hypothetical protein -
MR177_RS14410 3119747..3119958 - 212 Protein_2846 (R)-hydratase -
MR177_RS14415 3119974..3120489 - 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
MR177_RS14420 3120464..3121324 - 861 WP_003416628.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T295302 WP_003899954.1 NZ_OW052570:c3116397-3116053 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT295302 WP_003899955.1 NZ_OW052570:c3116056-3115727 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
AlphaFold DB G0THF6

References