Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2730805..2732048 Replicon chromosome
Accession NC_021350
Organism Legionella pneumophila subsp. pneumophila str. Thunder Bay

Toxin (Protein)


Gene name HipT Uniprot ID Q5ZSZ6
Locus tag LP6_RS12365 Protein ID WP_010948074.1
Coordinates 2731110..2732048 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag LP6_RS12360 Protein ID WP_010948073.1
Coordinates 2730805..2731113 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP6_RS12330 2726241..2726606 + 366 WP_010948069.1 BRCT domain-containing protein -
LP6_RS12335 2726963..2727328 - 366 WP_010948070.1 TraK family protein -
LP6_RS12340 2727513..2727653 - 141 WP_153802426.1 hypothetical protein -
LP6_RS12345 2727656..2729407 - 1752 WP_010948071.1 DUF927 domain-containing protein -
LP6_RS12350 2729473..2729748 - 276 WP_010948072.1 helix-turn-helix domain-containing protein -
LP6_RS12355 2730581..2730808 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
LP6_RS12360 2730805..2731113 + 309 WP_010948073.1 HipA N-terminal domain-containing protein Antitoxin
LP6_RS12365 2731110..2732048 + 939 WP_010948074.1 lpg2370 family Dot/Icm T4SS effector Toxin
LP6_RS12375 2732591..2733205 + 615 WP_010948075.1 hypothetical protein -
LP6_RS12380 2733361..2733567 - 207 WP_015444115.1 hypothetical protein -
LP6_RS12385 2733904..2735172 + 1269 WP_010948076.1 lpg2372 family Dot/Icm T4SS effector -
LP6_RS12390 2735388..2735913 - 526 Protein_2419 hypothetical protein -
LP6_RS12395 2735913..2736578 - 666 WP_015444114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36077.81 Da        Isoelectric Point: 8.6882

>T29521 WP_010948074.1 NC_021350:2731110-2732048 [Legionella pneumophila subsp. pneumophila str. Thunder Bay]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

>T29521 NC_021350:2731110-2732048 [Legionella pneumophila subsp. pneumophila str. Thunder Bay]
ATGAAACACTGCCCTATTACTTATGAAAAGATTAGTGACCAGGAAAACTATTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAACCTTAGTCCATTGGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTGTTCAAGGCGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAAGGCTGTTTTGAAATCGTGGATCAATATGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTAACCTACTTCATTAAACGCTTTGATA
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTAATTGCAGTCATAGAACAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCTTGGTCGGTAATGAAGACATGCATCTAAAAAACTTTTCCTTAATTACGAAGGATAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACCATCGCTCAAAAAAACACAAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCATTGAAAAATTAGGATTAAACCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGCTTCAGTTTTTTATCTCAAGAGATGC
AGGAAAAATATCTCGAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT29521 WP_010948073.1 NC_021350:2730805-2731113 [Legionella pneumophila subsp. pneumophila str. Thunder Bay]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT29521 NC_021350:2730805-2731113 [Legionella pneumophila subsp. pneumophila str. Thunder Bay]
ATGAGAAAAGCATACGTATCGGTGAGTGGCATTAAGGCTGGAATATTAGAAGAATTACAAGGTGGAACCTATCAATTTAC
CTACTTTGAGGATTATCACGGCGCACCTGTTTCACTCACTATGCCGTTGAAAAATAAGGTCTATGATTTTGACGTGTTCC
CCCCTTTTTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATACAAGATAGATAAAAATGAT
TATTTTGGTCAATTGATACTAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VKC
PDB 7VKB
PDB 7WCF

Antitoxin

Source ID Structure
PDB 7VKB
AlphaFold DB Q5ZSZ7

References