Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 120735..121603 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag MR176_RS00585 Protein ID WP_010886136.1
Coordinates 121226..121603 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag MR176_RS00580 Protein ID WP_003409886.1
Coordinates 120735..121184 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS00540 116520..117740 + 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
MR176_RS00545 117773..118045 + 273 WP_031651155.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR176_RS00550 118049..118456 + 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
MR176_RS00555 118616..119110 - 495 WP_003899099.1 hypothetical protein -
MR176_RS00560 119097..119348 + 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
MR176_RS00565 119345..119641 + 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
MR176_RS00570 119690..120304 + 615 WP_003901296.1 hypothetical protein -
MR176_RS00575 120193..120738 - 546 WP_003409891.1 SecB-like chaperone -
MR176_RS00580 120735..121184 - 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
MR176_RS00585 121226..121603 - 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
MR176_RS00590 121578..122099 + 522 WP_003904745.1 hypothetical protein -
MR176_RS00595 122073..122384 - 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
MR176_RS00600 122381..122596 - 216 WP_003409878.1 antitoxin -
MR176_RS00605 122836..123132 + 297 WP_003409877.1 hypothetical protein -
MR176_RS00610 123133..123324 + 192 WP_003409876.1 hypothetical protein -
MR176_RS00615 123345..124247 + 903 WP_003899097.1 hypothetical protein -
MR176_RS00620 124258..124608 + 351 WP_003409871.1 hypothetical protein -
MR176_RS00625 124722..124904 + 183 WP_003409870.1 hypothetical protein -
MR176_RS00630 124897..125298 - 402 WP_003409869.1 hypothetical protein -
MR176_RS00635 125362..125814 + 453 WP_003899095.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T295207 WP_010886136.1 NZ_OW052302:c121603-121226 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT295207 WP_003409886.1 NZ_OW052302:c121184-120735 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References