Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4106292..4107211 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name HigB2 Uniprot ID L7N4R2
Locus tag MR259_RS19230 Protein ID WP_003900449.1
Coordinates 4106606..4107211 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag MR259_RS19225 Protein ID WP_003410124.1
Coordinates 4106292..4106597 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS19190 4101555..4101755 + 201 Protein_3791 hypothetical protein -
MR259_RS19200 4103111..4103488 + 378 Protein_3793 hypothetical protein -
MR259_RS19205 4103485..4104525 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
MR259_RS19210 4104767..4105486 + 720 WP_003410108.1 DUF433 domain-containing protein -
MR259_RS19215 4105476..4105892 + 417 WP_003410114.1 hypothetical protein -
MR259_RS19220 4105908..4106207 - 300 WP_003410120.1 hypothetical protein -
MR259_RS19225 4106292..4106597 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
MR259_RS19230 4106606..4107211 - 606 WP_003900449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MR259_RS19235 4107236..4107595 - 360 WP_003410131.1 hypothetical protein -
MR259_RS19240 4107755..4108345 - 591 WP_223695536.1 hypothetical protein -
MR259_RS19245 4108384..4108620 - 237 WP_003410133.1 hypothetical protein -
MR259_RS19250 4108827..4109723 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T295197 WP_003900449.1 NZ_OW052189:c4107211-4106606 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT295197 WP_003410124.1 NZ_OW052189:c4106597-4106292 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BV20

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References