295158

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1228392..1229059 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag MR259_RS05780 Protein ID WP_003417916.1
Coordinates 1228392..1228784 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag MR259_RS05785 Protein ID WP_003912214.1
Coordinates 1228784..1229059 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS05760 1224239..1225228 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MR259_RS05765 1225228..1225617 - 390 Protein_1137 polyprenyl synthetase family protein -
MR259_RS05770 1225670..1226931 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
MR259_RS05775 1226973..1227638 - 666 Protein_1139 polyprenyl synthetase family protein -
MR259_RS05780 1228392..1228784 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS05785 1228784..1229059 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR259_RS05790 1229241..1230612 + 1372 Protein_1142 ISNCY family transposase -
MR259_RS05795 1230802..1232979 + 2178 WP_016330440.1 PE family protein -
MR259_RS05800 1233050..1233922 - 873 WP_031716378.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 1225670..1230612 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T295158 WP_003417916.1 NZ_OW052189:c1228784-1228392 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT295158 WP_003912214.1 NZ_OW052189:c1229059-1228784 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References