Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 975219..975913 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag MR259_RS04700 Protein ID WP_003899954.1
Coordinates 975219..975563 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MR259_RS04705 Protein ID WP_017487555.1
Coordinates 975560..975913 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS04665 970383..970594 + 212 Protein_918 (R)-hydratase -
MR259_RS04670 970607..970900 + 294 WP_003416635.1 hypothetical protein -
MR259_RS04675 970966..972227 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
MR259_RS04680 972546..972686 + 141 Protein_921 ATP-binding protein -
MR259_RS04690 974099..974533 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
MR259_RS04695 974536..974988 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR259_RS04700 975219..975563 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MR259_RS04705 975560..975913 + 354 WP_017487555.1 XRE family transcriptional regulator Antitoxin
MR259_RS04715 977786..978133 + 348 WP_003899956.1 DUF2384 domain-containing protein -
MR259_RS04720 978130..978750 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
MR259_RS04725 978910..980175 - 1266 WP_003902423.1 hypothetical protein -
MR259_RS04730 980343..980552 + 210 WP_003416778.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 970966..995077 24111
- inside IScluster/Tn - - 970966..977179 6213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T295155 WP_003899954.1 NZ_OW052189:975219-975563 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 12613.32 Da        Isoelectric Point: 7.4053

>AT295155 WP_017487555.1 NZ_OW052189:975560-975913 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVVNRPGESGDSLI

Download         Length: 354 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure

References