Detailed information of TA system TA295155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 975219..975913
• Replicon: chromosome
• Accession: NZ_OW052189
• Organism: Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)

• Gene name: higB
• Uniprot ID: O53332
• Locus tag: MR259_RS04700
• Protein ID: WP_003899954.1
• Coordinates: 975219..975563 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MR259_RS04705
• Protein ID: WP_017487555.1
• Coordinates: 975560..975913 (+)
• Length: 118 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	970966..995077	24111
	-	inside	IScluster/Tn	-	-	970966..977179	6213

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-91)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12692.50 Da
• Isoelectric Point: 5.6920

>T295155 WP_003899954.1 NZ_OW052189:975219-975563 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Nucleotide

• Length: 345 bp

Antitoxin

Protein

• Length: 118 a.a.
• Molecular weight: 12613.32 Da
• Isoelectric Point: 7.4053

>AT295155 WP_017487555.1 NZ_OW052189:975560-975913 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVVNRPGESGDSLI

Nucleotide

• Length: 354 bp

Structures

Toxin

• AlphaFold DB: A0A7U4FBK2