Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 2701052..2701740 Replicon chromosome
Accession NC_021286
Organism Idiomarina loihiensis GSL 199

Toxin (Protein)


Gene name yafO Uniprot ID Q5QV98
Locus tag K734_RS12910 Protein ID WP_011235748.1
Coordinates 2701052..2701450 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID Q5QV97
Locus tag K734_RS12915 Protein ID WP_011235749.1
Coordinates 2701447..2701740 (-) Length 98 a.a.

Genomic Context

K734_RS12870K734_RS12875K734_RS12890K734_RS12895K734_RS12905K734_RS12925K734_RS12930K734_RS12880K734_RS12885K734_RS12900K734_RS12910K734_RS12915K734_RS12920K734_RS12935
Location: 2696171..2696401 (231 bp)
Type: Others
Protein ID: WP_011235740.1
Location: 2696398..2696847 (450 bp)
Type: Others
Protein ID: WP_011235741.1
Location: 2699057..2699350 (294 bp)
Type: Others
Protein ID: WP_011235744.1
Location: 2699362..2699685 (324 bp)
Type: Others
Protein ID: WP_011235745.1
Location: 2700387..2701055 (669 bp)
Type: Others
Protein ID: WP_011235747.1
Location: 2703107..2703622 (516 bp)
Type: Others
Protein ID: WP_011235751.1
Location: 2703920..2705179 (1260 bp)
Type: Others
Protein ID: WP_011235752.1
Location: 2696862..2697569 (708 bp)
Type: Others
Protein ID: WP_011235742.1
Location: 2697572..2698852 (1281 bp)
Type: Others
Protein ID: WP_011235743.1
Location: 2699707..2700195 (489 bp)
Type: Others
Protein ID: WP_011235746.1
Location: 2701052..2701450 (399 bp)
Type: Toxin
Protein ID: WP_011235748.1
Location: 2701447..2701740 (294 bp)
Type: Antitoxin
Protein ID: WP_011235749.1
Location: 2701834..2702976 (1143 bp)
Type: Others
Protein ID: WP_011235750.1
Location: 2705157..2706482 (1326 bp)
Type: Others
Protein ID: WP_011235753.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K734_RS128702696171..2696401+231WP_011235740.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
K734_RS128752696398..2696847+450WP_011235741.1type II toxin-antitoxin system VapC family toxin-
K734_RS128802696862..2697569-708WP_011235742.1ZIP family metal transporter-
K734_RS128852697572..2698852-1281WP_011235743.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
K734_RS128902699057..2699350+294WP_011235744.1type II toxin-antitoxin system RelE/ParE family toxin-
K734_RS128952699362..2699685+324WP_011235745.1HigA family addiction module antidote protein-
K734_RS129002699707..2700195-489WP_011235746.1hypothetical protein-
K734_RS129052700387..2701055+669WP_011235747.1hypothetical protein-
K734_RS129102701052..2701450-399WP_011235748.1type II toxin-antitoxin system YafO family toxinToxin
K734_RS129152701447..2701740-294WP_011235749.1type I toxin-antitoxin system antitoxin YafNAntitoxin
K734_RS129202701834..2702976-1143WP_011235750.1alpha/beta hydrolase-
K734_RS129252703107..2703622+516WP_011235751.1DNA mismatch endonuclease Vsr-
K734_RS129302703920..2705179+1260WP_011235752.1DNA (cytosine-5-)-methyltransferase-
K734_RS129352705157..2706482-1326WP_011235753.1MspI family type II restriction endonuclease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15407.84 Da        Isoelectric Point: 7.0384

>T29515 WP_011235748.1 NC_021286:c2701450-2701052 [Idiomarina loihiensis GSL 199]
VIRVFKSKQIRQQLTDIELDALVKDFKRYKSGEGVPDLFGRDERYDHPDTFPVLRDNEVMHLHLQDPDEPWPLHCIQFAK
KSDTHLVYCPAAMTPNCYLLMIILDPPAHNKAWSSAVMLPLGIMAEKFRNRY

Download         Length: 399 bp

>T29515 NC_021286:c2701450-2701052 [Idiomarina loihiensis GSL 199]
GTGATTCGGGTTTTTAAGAGCAAACAGATTCGTCAGCAATTAACTGATATTGAACTGGATGCATTAGTAAAAGACTTTAA
GCGCTATAAAAGTGGCGAGGGCGTGCCTGACCTGTTCGGGCGCGATGAACGCTATGATCATCCAGATACCTTCCCGGTTC
TTCGTGACAATGAAGTAATGCATTTGCATCTACAAGATCCCGATGAGCCTTGGCCTTTGCATTGCATTCAGTTTGCTAAG
AAAAGTGATACGCACTTAGTCTATTGTCCGGCAGCTATGACGCCCAACTGCTATTTGCTTATGATAATTCTTGATCCTCC
TGCTCACAACAAAGCATGGAGCAGTGCGGTTATGCTACCCCTAGGAATAATGGCAGAAAAATTCCGTAATCGGTATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10759.25 Da        Isoelectric Point: 4.9001

>AT29515 WP_011235749.1 NC_021286:c2701740-2701447 [Idiomarina loihiensis GSL 199]
MNTQTILAEKTVSASDVRKHPCQYFEAEPVAVLSHNKTAGYMVGAELFEAMVRQLEACNPKVESLFRPTTARLKAISAEA
EKLLAEAKKSDLDDFEE

Download         Length: 294 bp

>AT29515 NC_021286:c2701740-2701447 [Idiomarina loihiensis GSL 199]
ATGAACACACAAACTATATTGGCTGAAAAAACGGTATCTGCCAGTGACGTGCGCAAACACCCCTGCCAGTATTTTGAAGC
TGAGCCTGTGGCGGTACTTTCCCACAATAAAACCGCTGGTTACATGGTAGGTGCTGAGTTATTTGAAGCTATGGTACGCC
AGTTGGAAGCCTGTAACCCTAAAGTAGAGTCCCTTTTTAGGCCGACGACAGCGCGGCTAAAGGCTATTAGTGCCGAAGCA
GAGAAGCTTTTAGCTGAAGCGAAAAAGTCTGATCTGGATGACTTTGAAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ5QV98

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A432YT68

References