Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 2701052..2701740 | Replicon | chromosome |
| Accession | NC_021286 | ||
| Organism | Idiomarina loihiensis GSL 199 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | Q5QV98 |
| Locus tag | K734_RS12910 | Protein ID | WP_011235748.1 |
| Coordinates | 2701052..2701450 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | Q5QV97 |
| Locus tag | K734_RS12915 | Protein ID | WP_011235749.1 |
| Coordinates | 2701447..2701740 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K734_RS12870 | 2696171..2696401 | + | 231 | WP_011235740.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| K734_RS12875 | 2696398..2696847 | + | 450 | WP_011235741.1 | type II toxin-antitoxin system VapC family toxin | - |
| K734_RS12880 | 2696862..2697569 | - | 708 | WP_011235742.1 | ZIP family metal transporter | - |
| K734_RS12885 | 2697572..2698852 | - | 1281 | WP_011235743.1 | deoxyguanosinetriphosphate triphosphohydrolase family protein | - |
| K734_RS12890 | 2699057..2699350 | + | 294 | WP_011235744.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K734_RS12895 | 2699362..2699685 | + | 324 | WP_011235745.1 | HigA family addiction module antidote protein | - |
| K734_RS12900 | 2699707..2700195 | - | 489 | WP_011235746.1 | hypothetical protein | - |
| K734_RS12905 | 2700387..2701055 | + | 669 | WP_011235747.1 | hypothetical protein | - |
| K734_RS12910 | 2701052..2701450 | - | 399 | WP_011235748.1 | type II toxin-antitoxin system YafO family toxin | Toxin |
| K734_RS12915 | 2701447..2701740 | - | 294 | WP_011235749.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| K734_RS12920 | 2701834..2702976 | - | 1143 | WP_011235750.1 | alpha/beta hydrolase | - |
| K734_RS12925 | 2703107..2703622 | + | 516 | WP_011235751.1 | DNA mismatch endonuclease Vsr | - |
| K734_RS12930 | 2703920..2705179 | + | 1260 | WP_011235752.1 | DNA (cytosine-5-)-methyltransferase | - |
| K734_RS12935 | 2705157..2706482 | - | 1326 | WP_011235753.1 | MspI family type II restriction endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15407.84 Da Isoelectric Point: 7.0384
>T29515 WP_011235748.1 NC_021286:c2701450-2701052 [Idiomarina loihiensis GSL 199]
VIRVFKSKQIRQQLTDIELDALVKDFKRYKSGEGVPDLFGRDERYDHPDTFPVLRDNEVMHLHLQDPDEPWPLHCIQFAK
KSDTHLVYCPAAMTPNCYLLMIILDPPAHNKAWSSAVMLPLGIMAEKFRNRY
VIRVFKSKQIRQQLTDIELDALVKDFKRYKSGEGVPDLFGRDERYDHPDTFPVLRDNEVMHLHLQDPDEPWPLHCIQFAK
KSDTHLVYCPAAMTPNCYLLMIILDPPAHNKAWSSAVMLPLGIMAEKFRNRY
Download Length: 399 bp
>T29515 NC_021286:c2701450-2701052 [Idiomarina loihiensis GSL 199]
GTGATTCGGGTTTTTAAGAGCAAACAGATTCGTCAGCAATTAACTGATATTGAACTGGATGCATTAGTAAAAGACTTTAA
GCGCTATAAAAGTGGCGAGGGCGTGCCTGACCTGTTCGGGCGCGATGAACGCTATGATCATCCAGATACCTTCCCGGTTC
TTCGTGACAATGAAGTAATGCATTTGCATCTACAAGATCCCGATGAGCCTTGGCCTTTGCATTGCATTCAGTTTGCTAAG
AAAAGTGATACGCACTTAGTCTATTGTCCGGCAGCTATGACGCCCAACTGCTATTTGCTTATGATAATTCTTGATCCTCC
TGCTCACAACAAAGCATGGAGCAGTGCGGTTATGCTACCCCTAGGAATAATGGCAGAAAAATTCCGTAATCGGTATTAG
GTGATTCGGGTTTTTAAGAGCAAACAGATTCGTCAGCAATTAACTGATATTGAACTGGATGCATTAGTAAAAGACTTTAA
GCGCTATAAAAGTGGCGAGGGCGTGCCTGACCTGTTCGGGCGCGATGAACGCTATGATCATCCAGATACCTTCCCGGTTC
TTCGTGACAATGAAGTAATGCATTTGCATCTACAAGATCCCGATGAGCCTTGGCCTTTGCATTGCATTCAGTTTGCTAAG
AAAAGTGATACGCACTTAGTCTATTGTCCGGCAGCTATGACGCCCAACTGCTATTTGCTTATGATAATTCTTGATCCTCC
TGCTCACAACAAAGCATGGAGCAGTGCGGTTATGCTACCCCTAGGAATAATGGCAGAAAAATTCCGTAATCGGTATTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10759.25 Da Isoelectric Point: 4.9001
>AT29515 WP_011235749.1 NC_021286:c2701740-2701447 [Idiomarina loihiensis GSL 199]
MNTQTILAEKTVSASDVRKHPCQYFEAEPVAVLSHNKTAGYMVGAELFEAMVRQLEACNPKVESLFRPTTARLKAISAEA
EKLLAEAKKSDLDDFEE
MNTQTILAEKTVSASDVRKHPCQYFEAEPVAVLSHNKTAGYMVGAELFEAMVRQLEACNPKVESLFRPTTARLKAISAEA
EKLLAEAKKSDLDDFEE
Download Length: 294 bp
>AT29515 NC_021286:c2701740-2701447 [Idiomarina loihiensis GSL 199]
ATGAACACACAAACTATATTGGCTGAAAAAACGGTATCTGCCAGTGACGTGCGCAAACACCCCTGCCAGTATTTTGAAGC
TGAGCCTGTGGCGGTACTTTCCCACAATAAAACCGCTGGTTACATGGTAGGTGCTGAGTTATTTGAAGCTATGGTACGCC
AGTTGGAAGCCTGTAACCCTAAAGTAGAGTCCCTTTTTAGGCCGACGACAGCGCGGCTAAAGGCTATTAGTGCCGAAGCA
GAGAAGCTTTTAGCTGAAGCGAAAAAGTCTGATCTGGATGACTTTGAAGAGTGA
ATGAACACACAAACTATATTGGCTGAAAAAACGGTATCTGCCAGTGACGTGCGCAAACACCCCTGCCAGTATTTTGAAGC
TGAGCCTGTGGCGGTACTTTCCCACAATAAAACCGCTGGTTACATGGTAGGTGCTGAGTTATTTGAAGCTATGGTACGCC
AGTTGGAAGCCTGTAACCCTAAAGTAGAGTCCCTTTTTAGGCCGACGACAGCGCGGCTAAAGGCTATTAGTGCCGAAGCA
GAGAAGCTTTTAGCTGAAGCGAAAAAGTCTGATCTGGATGACTTTGAAGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q5QV98 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A432YT68 |