295133

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 3688385..3689253 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag MR221_RS17325 Protein ID WP_010886136.1
Coordinates 3688876..3689253 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag MR221_RS17320 Protein ID WP_003409886.1
Coordinates 3688385..3688834 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS17280 3684170..3685390 + 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
MR221_RS17285 3685423..3685695 + 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR221_RS17290 3685699..3686106 + 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
MR221_RS17295 3686266..3686760 - 495 WP_003899099.1 hypothetical protein -
MR221_RS17300 3686747..3686998 + 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
MR221_RS17305 3686995..3687291 + 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
MR221_RS17310 3687340..3687954 + 615 WP_003901296.1 hypothetical protein -
MR221_RS17315 3687843..3688388 - 546 WP_003409891.1 SecB-like chaperone -
MR221_RS17320 3688385..3688834 - 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
MR221_RS17325 3688876..3689253 - 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
MR221_RS17330 3689228..3689749 + 522 WP_003904745.1 hypothetical protein -
MR221_RS17335 3689723..3690034 - 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
MR221_RS17340 3690031..3690246 - 216 WP_003409878.1 antitoxin -
MR221_RS17345 3690486..3690782 + 297 WP_003409877.1 hypothetical protein -
MR221_RS17350 3690783..3690974 + 192 WP_003409876.1 hypothetical protein -
MR221_RS17355 3690995..3691897 + 903 WP_003409874.1 hypothetical protein -
MR221_RS17360 3691908..3692258 + 351 WP_242363164.1 hypothetical protein -
MR221_RS17365 3692372..3692554 + 183 WP_003409870.1 hypothetical protein -
MR221_RS17370 3692547..3692948 - 402 WP_003409869.1 hypothetical protein -
MR221_RS17375 3693012..3693464 + 453 WP_003899095.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T295133 WP_010886136.1 NZ_OW052188:c3689253-3688876 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT295133 WP_003409886.1 NZ_OW052188:c3688834-3688385 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References