295127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3618749..3619668 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name HigB2 Uniprot ID L7N4R2
Locus tag MR221_RS16920 Protein ID WP_003900449.1
Coordinates 3618749..3619354 (+) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag MR221_RS16925 Protein ID WP_003410124.1
Coordinates 3619363..3619668 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS16900 3616237..3617133 + 897 WP_242363159.1 hypothetical protein -
MR221_RS16905 3617340..3617576 + 237 WP_003410133.1 hypothetical protein -
MR221_RS16910 3617615..3618205 + 591 WP_057145698.1 hypothetical protein -
MR221_RS16915 3618365..3618724 + 360 WP_003410131.1 hypothetical protein -
MR221_RS16920 3618749..3619354 + 606 WP_003900449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MR221_RS16925 3619363..3619668 + 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
MR221_RS16930 3619753..3620052 + 300 WP_003410120.1 hypothetical protein -
MR221_RS16935 3620068..3620484 - 417 WP_003410114.1 hypothetical protein -
MR221_RS16940 3620474..3621193 - 720 WP_003410108.1 DUF433 domain-containing protein -
MR221_RS16945 3621435..3622475 - 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
MR221_RS16950 3622472..3623047 - 576 WP_003410100.1 hypothetical protein -
MR221_RS16955 3623401..3624657 + 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T295127 WP_003900449.1 NZ_OW052188:3618749-3619354 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT295127 WP_003410124.1 NZ_OW052188:3619363-3619668 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BV20

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BV30

References