295110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2339880..2340550 Replicon chromosome
Accession NZ_OW052188
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag MR221_RS10825 Protein ID WP_003899954.1
Coordinates 2340206..2340550 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MR221_RS10820 Protein ID WP_242363115.1
Coordinates 2339880..2340209 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR221_RS10790 2335295..2336329 + 1035 WP_003905011.1 IS30 family transposase -
MR221_RS10795 2336356..2336541 - 186 WP_003908177.1 hypothetical protein -
MR221_RS10800 2336576..2336785 - 210 WP_003416778.1 hypothetical protein -
MR221_RS10805 2336953..2338218 + 1266 WP_003909837.1 hypothetical protein -
MR221_RS10810 2338378..2338998 - 621 WP_003899957.1 RES family NAD+ phosphorylase -
MR221_RS10815 2338995..2339342 - 348 WP_003899956.1 DUF2384 domain-containing protein -
MR221_RS10820 2339880..2340209 - 330 WP_242363115.1 XRE family transcriptional regulator Antitoxin
MR221_RS10825 2340206..2340550 - 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MR221_RS10830 2340781..2341233 + 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR221_RS10835 2341236..2341670 + 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
MR221_RS10840 2342017..2343306 - 1290 WP_003416640.1 ATP-binding protein -
MR221_RS10845 2343594..2343887 - 294 WP_003416635.1 hypothetical protein -
MR221_RS10850 2343900..2344111 - 212 Protein_2144 (R)-hydratase -
MR221_RS10855 2344127..2344642 - 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
MR221_RS10860 2344617..2345477 - 861 WP_003416628.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

HigA2-like, helix-turn-helix domain

(35-98)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T295110 WP_003899954.1 NZ_OW052188:c2340550-2340206 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11743.39 Da        Isoelectric Point: 6.8811

>AT295110 WP_242363115.1 NZ_OW052188:c2340209-2339880 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGPVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure

References