Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 357813..358459 Replicon chromosome
Accession NZ_OV754010
Organism Klebsiella pneumoniae isolate BB1541

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag O0V11_RS01655 Protein ID WP_004174016.1
Coordinates 357813..358160 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag O0V11_RS01660 Protein ID WP_019725405.1
Coordinates 358160..358459 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0V11_RS01645 (VKR_00325) 353739..355172 + 1434 WP_002920564.1 glycogen synthase GlgA -
O0V11_RS01650 (VKR_00326) 355190..357637 + 2448 WP_002920561.1 glycogen phosphorylase -
O0V11_RS01655 (VKR_00327) 357813..358160 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O0V11_RS01660 (VKR_00328) 358160..358459 + 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
O0V11_RS01665 (VKR_00329) 358522..360030 - 1509 WP_019704656.1 glycerol-3-phosphate dehydrogenase -
O0V11_RS01670 (VKR_00330) 360235..360564 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
O0V11_RS01675 (VKR_00331) 360615..361445 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
O0V11_RS01680 (VKR_00332) 361495..362253 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T295054 WP_004174016.1 NZ_OV754010:357813-358160 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT295054 WP_019725405.1 NZ_OV754010:358160-358459 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References