Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2357977..2358494 Replicon chromosome
Accession NZ_OV648025
Organism Staphylococcus argenteus isolate 20S00001-1_long

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7U7PWL3
Locus tag MD993_RS11295 Protein ID WP_031787172.1
Coordinates 2357977..2358243 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7PWU0
Locus tag MD993_RS11300 Protein ID WP_031787173.1
Coordinates 2358243..2358494 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MD993_RS11270 2353407..2353943 - 537 WP_031787169.1 GNAT family N-acetyltransferase -
MD993_RS11275 2354176..2355000 - 825 WP_000572040.1 formate/nitrite transporter family protein -
MD993_RS11280 2355217..2355402 - 186 WP_000230291.1 hypothetical protein -
MD993_RS11285 2355486..2355953 - 468 WP_031787170.1 SRPBCC domain-containing protein -
MD993_RS11290 2356136..2357680 - 1545 WP_031787171.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MD993_RS11295 2357977..2358243 - 267 WP_031787172.1 Txe/YoeB family addiction module toxin Toxin
MD993_RS11300 2358243..2358494 - 252 WP_031787173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MD993_RS11305 2358766..2359365 - 600 WP_000162802.1 DsbA family protein -
MD993_RS11310 2359385..2359747 - 363 WP_031787174.1 DUF4467 domain-containing protein -
MD993_RS11315 2360001..2361251 + 1251 WP_031787175.1 aminoacyltransferase -
MD993_RS11320 2361346..2362077 - 732 WP_000615469.1 amino acid ABC transporter ATP-binding protein -
MD993_RS11325 2362074..2362793 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10511.99 Da        Isoelectric Point: 9.7791

>T295024 WP_031787172.1 NZ_OV648025:c2358243-2357977 [Staphylococcus argenteus]
MARLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALQGIGKPEKLKSNLFGYYSRRINHEHRLVYTVDDNHIK
IASCRYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9395.56 Da        Isoelectric Point: 4.3558

>AT295024 WP_031787173.1 NZ_OV648025:c2358494-2358243 [Staphylococcus argenteus]
MIVKNYSYARQNLKTLMTKVNDDSDVVTVTSTDDKNVVIMSEADYNSIIETLYLQQNPNNAEHLAQSIADLERGKMVTKE
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PWL3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7PWU0

References