Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2486005..2486694 Replicon chromosome
Accession NZ_OV408202
Organism Klebsiella pneumoniae isolate CNR146C9

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag NBX86_RS12125 Protein ID WP_021469727.1
Coordinates 2486005..2486322 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag NBX86_RS12130 Protein ID WP_020804705.1
Coordinates 2486398..2486694 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX86_RS12095 (2481707) 2481707..2482216 + 510 WP_020802144.1 GNAT family N-acetyltransferase -
NBX86_RS12100 (2482226) 2482226..2483152 + 927 WP_032435210.1 amino acid ABC transporter permease -
NBX86_RS12105 (2483136) 2483136..2483915 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
NBX86_RS12110 (2483954) 2483954..2484805 + 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
NBX86_RS12115 (2484883) 2484883..2485500 + 618 WP_032425015.1 glutathione S-transferase family protein -
NBX86_RS12120 (2485571) 2485571..2485798 + 228 WP_002906690.1 tautomerase PptA -
NBX86_RS12125 (2486005) 2486005..2486322 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBX86_RS12130 (2486398) 2486398..2486694 + 297 WP_020804705.1 NadS family protein Antitoxin
NBX86_RS12135 (2486773) 2486773..2487219 + 447 WP_032435212.1 hypothetical protein -
NBX86_RS12140 (2487260) 2487260..2488876 - 1617 WP_004175961.1 carbohydrate porin -
NBX86_RS12145 (2488920) 2488920..2490302 - 1383 WP_004151222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T295010 WP_021469727.1 NZ_OV408202:2486005-2486322 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT295010 WP_020804705.1 NZ_OV408202:2486398-2486694 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References