Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 350740..351386 Replicon chromosome
Accession NZ_OV408202
Organism Klebsiella pneumoniae isolate CNR146C9

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag NBX86_RS01620 Protein ID WP_016529833.1
Coordinates 350740..351087 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag NBX86_RS01625 Protein ID WP_002920557.1
Coordinates 351087..351386 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX86_RS01610 (346676) 346676..348109 + 1434 WP_002920564.1 glycogen synthase GlgA -
NBX86_RS01615 (348127) 348127..350574 + 2448 WP_002920561.1 glycogen phosphorylase -
NBX86_RS01620 (350740) 350740..351087 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBX86_RS01625 (351087) 351087..351386 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
NBX86_RS01630 (351449) 351449..352957 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
NBX86_RS01635 (353162) 353162..353491 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NBX86_RS01640 (353542) 353542..354372 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
NBX86_RS01645 (354422) 354422..355180 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T295004 WP_016529833.1 NZ_OV408202:350740-351087 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT295004 WP_002920557.1 NZ_OV408202:351087-351386 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References